Holloway was 18 years old when she went on vacation in the Caribbean, where she was celebrating her high school graduation with friends.
There, she met a man named Joran van der Sloot, who was later questioned by police for possible involvement in her disappearance but was released due to a lack of evidence.
Gardner was 35 years old when she went missing in 2011 on vacation with a man she met through an online dating site, People reports.
He told police Gardner was swept away by a strong current while they were snorkeling together.
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She is one of four Americans to go missing in the Caribbean in recent years, according to the Huffington Post.
Van der Sloot is now serving time in jail for murdering a 21-year-old female student.A human bone found in Aruba during an investigation into the disappearance of Natalee Holloway was tested and does not belong to the 18-year-old who went missing in 2005 -- but a new DNA test may link the bone to missing Maryland woman Robyn Gardner.Gardner’s sister, Danielle Colson-Unglesbee, said she will be submitting her DNA for tests to determine if the bone could be a match for Gardner.Many similarities exist between Holloway’s case and Gardner's.Both were American women who disappeared mysteriously in the same small town in Aruba.